Abstract:

Conference on Active Oxygen and Medicine, Honolulu, Hawaii, March 3-4 (1979)


Role of Active Oxygen Species in Ocular and Neurological Diseases

Peter H. Proctor, et al

" Electronically-activated species of oxygen such as superoxide or peroxide and their metabolic products may play a key role in the etiology of certain disorders of the eye and central nervous system. For example, in man, the chronic presence of elevated systemic levels of agents such as urate, homocysteine, or copper which can catalyze the production of such species and/or bind to melanin are often associated with on or more of four characteristic signs. These are psychotic behavior, movement disorders, deafness and pigmentary abnormalities. Likewise, the enzymes superoxide dismutase (SOD) or catalase are effective in the therapy of certain experimental lesions in animals such as high pressure oxygen toxicity, corneal alkali burns, and formalin-induced posterior segment uveitis. We suggest that active oxygen metabolites act as specific intermediary transmitter substances for a variety of biological processes including inflammation, fibrosis, and possibly, neurotransmission. "

For earlier review. go here

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Keywords: homocysteine melanin organic semiconductor conductive polymers redox signaling nitric oxide reactive oxygen species radical singlet ros messenger sod human disease.


 

 

 

 

 

 

 

Keywords: parkinsonism parkinson's disease neuromalanin melanin hemochromatosis free radical spin trap spin label melanin charge transfer lesch-nyhan bromism iodism wilson's disease manganism inflammation neurofibrillary tangles fibrosis cerovive (tm) nyx059 astrazenica prostaglandin superoxide dismutase sod hydrogen peroxide hydroxy radical reactive ozygen species etiology copper transition series metal redox signaling cytokine nkbeta amorphous semiconductor organic threshold switching electronic properties antioxidant proxidant oxidant oxidation reduction cancer altzheimer's disease spin trap label senile dementia pbn tempol tempo dmpo nxy-059 nitrone nitroxide.

drug treatment polyacetylene human diabetes alcaptonuria homogentisic phenothiazine proxidant vitamin c ascorbate vitamin e deafness deaf tardive pigmentary abnormalities albino ototoxic drug aminoglycoside waardenberg cis-platinum adriamycin bleomycin messenger uric acid urate iron manganese iodide dalmatian ataxia dyskinesia psychosis schizophrenia dementia vascular stria vascularis substantia nigra midbrain basil ganglia locus ceruleus pigmented stroke reperfusion injury fenton's reaction cytochrome c nitric oxide myocardia infarction mitochondria catalase glutathione peroxidase transmission neurotransmission.inner ear lung platelet interstitial ards dad pulmonary.edema asbestosis asbestos cardiac atherosclerosis heart homocystinuria active oxygen autoxidation autooxidation.

Schizophrenia parkinsonism parkinson's disease neuromalanin melanin hemochromatosis free radical spin trap spin label melanin sharge transfer Lesch-Nyhan bromism iodism wilson's disease dyskinesia manganism inflammation neurofibrillary tangles fibrosis deaf deafness prostaglandin superoxide dismutase sod superoxide hydrogen peroxide hydroxy radical reactive ozygen species etiology copper transition series metal redox signaling cytokine nkbeta amorphous semiconductor organic threshold switching electronic properties antioxidant proxidant oxidant oxidation reduction.

cancer altzheimer's disease senile dementia pbn tempol tempo dmpo nxy-059 nitrone nitroxide drug treatment polyacetylene human diabetes proxidant vitamin c ascorbate vitamin E deafness deaf phenothiazine pigmentary abnormalities albino ototoxic aminoglycoside cis-platinum adriamycin bleomycin messenger uric acid urate iron manganese iodide dalmatian ataxia dyskinesia psychosis schizophrenia dementia vascular stria vascularis locus caeruleus substantia nigra midbrain basil ganglia locus ceruleus pigmented stroke reperfusion injury nitric oxide myocardia infarction mitochondria pathogenesis free radical.